Table 1

Summary of steady-state gating parameters of Na+ channels

ChannelActivation (m)Inactivation (h)
V1/2kV1/2k
μ1−27.4  ± 3.1 (5)4.2  ± 0.7 (5)−66.0  ± 1.3 (6)6.4  ± 0.4 (6)
F1342I−27.0  ± 2.3 (5)4.9  ± 0.6 (5)−66.9  ± 2.0 (4)7.6  ± 0.4 (4)
I1354F−27.05  ± 2.2 (3)5.2  ± 0.6 (3)−62.3  ± 1.0 (6)7.7  ± 0.5 (6)
L1373E−33.0  ± 1.4 (9)1-a 4.5  ± 0.4 (9)−65.9  ± 2.9 (7)7.9  ± 0.8 (7)
D1376N/N1380K−30.6  ± 4.7 (3)4.7  ± 0.6 (3)−68.2  ± 2.6 (6)7.4  ± 0.5 (6)
Y1379A−29.9  ± 2.2 (3)3.9  ± 0.3 (3)−55.4  ± 1.2 (4)1-a 7.5  ± 0.3 (4)
G1408S−25.7  ± 2.4 (7)5.3  ± 0.4 (7)−64.0  ± 1.6 (7)8.0  ± 0.4 (7)
V1451I−29.5  ± 2.6 (3)4.3  ± 0.2 (3)−74.2  ± 1.9 (8)1-a 7.3  ± 0.3 (8)
hH1−46.9  ± 2.1 (8)1-a 4.1  ± 1.3 (8)−83.9  ± 6.3 (4)1-a 6.3  ± 0.4 (4)1-a
hH1-E1555L−35.8  ± 4.0 (7)ab 4.4  ± 0.5 (7)−83.0  ± 5.6 (3)1-a 5.8  ± 0.4 (3)1-a

Values are presented as mean ± S.E.M. Numbers in parentheses represent the number of individual determinations.

    • 1-a  Entries that are statistically different (p < 0.05) from wild-type μ1.

    • 1-b  hH1 construct statistically different from WT hH1 (p < 0.05).