nAChR populations expressed in monkey caudate-putamen
| Population | α Subunit | β Subunit | Ligand Sensitivity | Effect of MPTP |
|---|---|---|---|---|
| % | ||||
| α-ctx MII sensitive | α6 | β2, β3, β4 | A85380 > Cyt ≈ Nic > α-ctx MII | 100 ↓ |
| α-ctx MII insensitive | α4 | β2 | A85380 > Cyt ≈ Nic | 20 ↓ |
Subunits are inferred from mRNA expression and sensitivity to nAChR ligands (Quik et al., 2000a,b)
α-ctx MII, α-conotoxin MII; Nic, nicotine; Cyt, cytisine.