Table 1

Protocol and results of independent, single-step CQ selection experiments using the 106/1 line of P. falciparum

ExperimentNo. Flasks∼No. Parasites per FlaskNo. Positive FlasksDay Parasites ObservedPfCRT 76 Amino Acidpfcrt Codon 76
141.2  × 109 0
246.0  × 108 442–50NAAT
366.0  × 108 0
461.2  × 109 0
5103  × 109 21-a 28 and 31IATA
643  × 109 0

  • ↵1-a  Flask with parasites observed at day 31 contained 200 nM CQ.