Table 1

Effect of phenolic compounds on heme oxygenase activity in astrocytes

	Heme Oxygenase Activity
	5 μM	15 μM	30 μM	50 μM
	% control
Rosmarinic acid	97.6 ± 8.9	93.7 ± 1.6	83.0 ± 4.2^1-150	82.3 ± 2.6^1-150
Resveratrol	99.4 ± 1.9	83.2 ± 3.5^1-150	67.2 ± 7.4^1-150	19.0 ± 2.5^1-150
o-Coumaric acid	97.9 ± 0.5	99.5 ± 5.4	86.3 ± 4.1^1-150	74.0 ± 9.9^1-150
p-Coumaric acid	97.1 ± 0.3	63.3 ± 0.83^1-150	51.6 ± 1.7^1-150	43.5 ± 2.0^1-150

Astrocytes were incubated for 6 h with various polyphenolics at the concentrations indicated, and heme oxygenase activity was determined as described under Experimental Procedures.

↵1-150 p < 0.05 vs. control.