Cross | Phenotype | Chromosome | ||
---|---|---|---|---|
11 | 12 | 14 | ||
C57 × DBA | URO | 5.46 | 6.02 | 2.94 |
ALT | 1.33 | 1.54 | 0.75 | |
AST | 0.66 | 5.45 | 0.41 | |
Thymus | 0.93 | 5.70 | 0.59 | |
1 | 9 | 11 | ||
SWR × DBA | URO | 6.89 | 2.513-a | 11.84 |
ALT | 5.82 | 3.06 | 2.84 | |
Thymus | 1.15 | 0.69 | 1.02 |
A LOD score of 2.8 was taken to be statistically suggestive and 4.3 as significant (Lander and Kruglyak, 1995). Regression analysis was used to quantify the percent of variance of URO by the most statistically significant (as estimated by a one-way ANOVA) genetic markers. The ratio in the C57BL/6 × DBA/2 F2 cross was estimated as 1:1.75:0.88 for D11Mit179, Ahr, and D14Mit60 respectively. In the SWR × DBA/2 F2 cross, 1:0.08:1.21 for D1Mit14, D9Mit15, and D11Mit70 respectively.
↵3-a Although just lower than LOD 2.8, D9Mit15 and D9Mit17 gave significant linkage (p < 0.05) with URO by χ2 analysis.