Table 1

Angiotensin II analogs used in this study

Peptide	1	2	3	4	5	6	7	8	Code	K_D(AT1R)	Max IP Production
										nM	%
AngII	NH ₂-Asp-	Arg-	Val-	Tyr-	Val-	His-	Pro-	Phe-COOH		1.6^1-a	100
[Sar¹Ala⁴]AngII	Sar-	Arg-	Val-	Ala-	Val-	His-	Pro-	Phe-COOH	(A4)	150^1-a	90^1-a
[Sar¹Ala⁸]AngII	Sar-	Arg-	Val-	Tyr-	Val-	His-	Pro-	Ala-COOH	(A8)	0.9^1-a	18^1-a
[Sar¹Ile⁴Ile⁸]AngII	Sar-	Arg-	Val-	Ile-	Val-	His-	Pro-	Ile-COOH	(I48)	300^1-a	0^1-a
[Sar¹Gly⁴Gly⁸]AngII	Sar-	Arg-	Val-	Gly	Val-	His-	Pro-	Gly-COOH	(G48)	310^1-c	0^1-c
AngIII	NH_2-	Arg-	Val-	Tyr-	Val-	His-	Pro-	Phe-COOH		8.9^1-c	86^1-c
[Ala¹]AngII	NH₂-Ala-	Arg-	Val-	Tyr-	Val-	His-	Pro-	Phe-COOH	(A1)	0.9^1-a	100^1-a
[Sar¹Gln²]AngII	Sar-	Gln-	Val-	Tyr-	Val-	His-	Pro-	Phe-COOH	(G2)	8.1^1-a	92^1-a
[Sar¹Ala³]AngII	Sar-	Arg-	Ala-	Tyr-	Val-	His-	Pro-	Phe-COOH	(A3)	18^1-a	95^1-a
[Sar¹Ala⁶]AngII	Sar-	Arg-	Val-	Tyr-	Val-	Ala-	Pro-	Phe-COOH	(A6)	103^1-a	92^1-a
[Sar¹Ala⁷]AngII	Sar-	Arg-	Val-	Tyr-	Val-	His-	Ala-	Phe-COOH	(A7)	91^1-a	98^1-a
[Sar¹]AngII-amide	Sar-	Arg-	Val-	Tyr-	Val-	His-	Pro-	Phe-CONH ₂	(Am)	7.3^1-a	85^1-b
[Sar¹Cha⁴]AngII	Sar-	Arg-	Val-	Cha-	Val-	His-	Pro-	Phe-COOH	(C4)	75.9^1-a	48^1-a
[Sar¹Cha⁸]AngII	Sar-	Arg-	Val-	Tyr-	Val-	His-	Pro-	Cha-COOH	(C8)	0.47^1-a	40^1-a
[Sar¹Ile⁸]AngII	Sar-	Arg-	Val-	Tyr-	Val-	His-	Pro-	Ile-COOH	(I8)	0.37^1-a	20^1-a
[Sar¹DiP⁸]AngII	Sar-	Arg-	Val-	Tyr-	Val-	His-	Pro-	DiP-COOH	(D8)	0.89^1-c	100^1-c

Maximum IP production is reported as a percentage of [Sar¹]-AngII.

Sar, sarcosine, N-methyl glycine; Cha, β-cyclohexylalanine; Dip, diphenylalanine
↵1-a Miura and Karnik (1999).
↵1-b Noda et al. (1995).
↵1-c S. Miura and S. S. Karnik, unpublished observations.