Table 1

In vitro inhibition of Cdc25B, VHR, and PTP1B by NCI compounds

NSC^#	IC₅₀
NSC^#	Cdc25B	VHR	PTP1B
	μM
4056	0.840 ± 0.066	N.D.	N.D.
5069	0.704 ± 0.066	6.1^1-a	≫10 μM^1-b
50554	0.650 ± 0.045	N.D.	N.D.
92217	0.546 ± 0.014	N.D.	N.D.
95397	0.125 ± 0.036	2.7 ± 0.550	2.3 ± 0.153
102381	0.457 ± 0.007	3.1 ± 0.005	4.4 ± 0.535
102539	0.642 ± 0.029	N.D.	13.2 ± 1.881
105326	0.870 ± 0.030	N.D.	31.1 ± 2.661
107043	0.780 ± 0.050	9.4 ± 0.850	39.0 ± 3.195
115447	0.450 ± 0.130	5.7 ± 0.650	11.9 ± 1.575
117271	0.940 ± 0.325	13^1-a	30.8 ± 2.509
125248	0.580 ± 0.062	N.D.	6.1 ± 1.226
128981	0.620 ± 0.100	13.1 ± 1.115	≫100 μM^1-c
129077	0.895 ± 0.033	N.D.	≫100 μM
129141	0.890 ± 0.092	N.D.	≫100 μM
130442	0.845 ± 0.046	N.D.	≫100 μM
135879	0.540 ± 0.035	N.D.	≫100 μM
135880	0.210 ± 0.071	6.9 ± 1.285	≫100 μM
139049	0.178 ± 0.051	1.8 ± 0.300	4.1 ± 1.224
327705	0.920^1-a	11^1-a	≫ 10 μM
668394	0.640 ± 0.130	8.5^1-a	16.4 ± 3.861

IC₅₀ values are the mean ± S.E.M. from three to four determinations using concentrations ranging from 0.005 to 10 μM, as described under Materials and Methods.

N.D., not determined.
↵1-a Single determination.
↵1-b Inhibition of <5% was detected at 10 μM.
↵1-c Inhibition of <5% was detected at 100 μM.