Table 3

Comparison of the DR3s from the rat CYP3A1 and oatp2

SequenceMismatch
Perfect DR3 (sense) 5′ AGT(T)TCAnnnAGT(T)TCA 3′
Perfect DR3 (antisense) 5′ TGA(A)ACTnnnTGA(A)ACT 3′
CYP3A1 DR3 (sense) 5′ AGTTCAtgaAGTTCA 3′
CYP3A1 DR3 (antisense) 5′ TGAACTtcaTGAACT 3′
DR3-1 (sense) 5′ AGCTCAagaAGTTCA 3′ 1
DR3-1 (antisense) 5′ TGAACTtctTGAGCT 3′
DR3-2 (sense) 5′ TGCACTgagTCCACT 3′ 3
DR3-2 (antisense) 5′ AGTGGActcAGTGCA 3′
DR3-3 (sense) 5′ TGACCTttaTGCCCT 3′ 1
DR3-3 (antisense) 5′ AGGGCAtaaAGGTCA 3′
DR3-4 (sense) 5′ GGATCTgatTGAACT 3′ 2
DR3-4 (antisense) 5′ AGTTCAatcAGATCC3′