MKN/ADR | |||
---|---|---|---|
Drug | MKN-45 (IC50) | IC50 | R |
μM | μM | ||
Berberrubine | 32.3 ± 1.7 | 201.0 ± 26.9 | 6.2 |
Etoposide | 24.0 ± 1.4 | 161.0 ± 46.7 | 6.7 |
Doxorubicin | 1.5 ± 0.4 | 9.7 ± 0.7 | 6.5 |
Mitoxantrone | 1.9 ± 0.1 | 4.8 ± 1.3 | 2.5 |
Berberine | 25.0 ± 8.5 | 25.8 ± 9.5 | 1.0 |
IC50 values were measured using the MTT assay. Values are means ± S.D. of three or more determinations. Resistance factor (R) was calculated as the ratio of IC50 values between MKN/ADR and MKN-45 cells