Summary of concentration-response data for tracazolate and etazolate potentiation of control GABA EC20 responses for wild type and mutant GABAA receptors
| Subunit Combination | EC50 | Maximum Potentiation | Hill Coefficient | No. of Oocytes |
|---|---|---|---|---|
| μM | ||||
| Tracazolate | ||||
| α1β1γ2s | 13.2 (10.2, 17.2) | 168 ± 16 | 1.54 ± 0.11 | 4 |
| α1β3γ2s | 1.5 (1.2, 1.8) | 224 ± 46 | 1.27 ± 0.12 | 5 |
| α1β1Ser265Asnγ2s | 2.7 (2.4, 2.9) | 273 ± 60 | 1.28 ± 0.12 | 4 |
| α1β3Asn265Serγ2s | 6.8 (5.5, 8.5) | 207 ± 24 | 1.10 ± 0.10 | 4 |
| α1β3 | 2.7 (2.0, 3.5) | 351 ± 94 | 1.24 ± 0.13 | 4 |
| α6β3γ2s | 1.1 (0.8, 1.6) | 363 ± 44 | 1.42 ± 0.18 | 4 |
| α1β1γ1 | 1.3 (1.1, 1.5) | 21.0 ± 5.9 | 1.8 ± 0.5 | 4 |
| α1β1γ3 | 1.4 (1.0, 2.1) | 34.7 ± 10.1 | 1.6 ± 0.7 | 4 |
| α1β1δ | 16.7 (14.6, 19.2) | 1368 ± 377 | 1.4 ± 0.06 | 5 |
| Etazolate | ||||
| α1β1γ2s | 8.3 (6.8, 10.2) | 315 ± 32 | 1.25 ± 0.09 | 4 |
| α1β3γ2s | 1.3 (1.1, 1.5) | 271 ± 34 | 1.91 ± 0.47 | 5 |
Data for the EC50 are the geometric mean (−S.E.M., +S.E.M.) and for the maximum potentiation and Hill coefficient are the arithmetic mean ± S.E.M.