Table 1

Deactivation kinetics for hKv1.4 and heptad leucine mutant channel constructs

Membrane Potentialτtails (± SDn − 1)
hKv1.4 (n = 8)L1F (n = 5)L2F (n = 6)L3F (n = 9)L4F (n = 11)L5F (n = 7)
mV ms
−1004.66 ± 1.192.38 ± 0.161.21 ± 0.832.72 ± 0.681.20 ± 0.462.26 ± 1.18
−905.22 ± 1.262.77 ± 0.851.42 ± 0.893.17 ± 0.391.41 ± 0.622.08 ± 0.67
−806.07 ± 2.153.13 ± 0.211.00 ± 0.503.61 ± 1.661.53 ± 0.443.20 ± 2.64
−707.43 ± 1.843.42 ± 0.251.21 ± 0.475.55 ± 2.441.51 ± 0.542.73 ± 1.82
−6010.86 ± 2.573.68 ± 0.881.19 ± 0.626.06 ± 1.991.79 ± 0.582.75 ± 1.42
−5014.98 ± 6.292.81 ± 1.341-a 1.40 ± 0.827.38 ± 1.811.68 ± 0.521-e 1.96 ± 0.881-b
−4011.37 ± 4.731-b 4.08 ± 1.411-a 1.72 ± 0.909.26 ± 1.682.36 ± 0.571-e 3.14 ± 1.681-c
−306.62 ± 3.991-b 5.40 ± 2.111-a 1.30 ± 0.789.60 ± 3.522.31 ± 0.461-e 2.78 ± 2.00
−205.74 ± 2.641-b 6.74 ± 2.881-a 1.60 ± 0.707.87 ± 4.551-d 2.31 ± 1.261-e 2.30 ± 0.541-a