Table 4

Vinblastine accumulation and calcein accumulation IC₅₀predictions with the inhibition of verapamil binding model

Molecule	ObservedK_i		Predicted IC₅₀ Verapamil Binding Model
Molecule	Vinblastine Accumulation Model	Calcein Accumulation Model	Predicted IC₅₀ Verapamil Binding Model
	μM		μM
Ergometrine	100	115.5	4500
Troleandomycin	87.64	483.3	2000
Amiodarone	–^4-a	5.78	47
Clotrimazole	29.92	44	2800
Erythromycin	37.79	1000	320
Fluconazole	400	1000	2700
Ketoconazole	5.27	24.9	90
Miconazole	26.36	55.5	340
Reserpine	0.97	12.2	78
Dihydroergotamine	119.94	1000	120
Ergocornine	24.5	105.2	100
Ergocristine	13.33	42.8	82
Ergotamine	14.25	98.9	83
Bromocriptine	3.96	2.81	89
Ergocryptine	6.43	12.2	120
Dihydroergocristine	16	511	77
Dihydroergocryptine	19.82	360.5	94
Cyclosporin	1.3	4.66	160