Table 1

Cholinesterase inhibition and potentiation of glutamatergic transmission by structurally unrelated cholinesterase inhibitors

DrugsIC50 (rat brain cholinesterase)EPSC AmplitudesPn
nM % control
Galantamine, 1 μM9201-a 120  ±  2.9<0.015
Methyl-galantamine, 1 μM119  ±  3.4<0.014
Methamidophos, 100 μM29,0001-b 105  ±  3.7 0.655
Metrifonate, 20 μM1,4401-c 97  ±  5.5 0.634
Donepezil
 10 nM6.71-c 101  ±  6.0 0.883
 100 nM94  ±  5.3 0.305
Rivastigmine
 10 nM4.31-c 98  ±  4.5 0.633
 100 nM100  ±  2.1 1.004

EPSCs were recorded from CA1 pyramidal neurons in response to field stimulation of the Schaffer collaterals in rat hippocampal slices.P values are from a comparison between control and treated groups using the paired Student's t test. n indicates number of neurons.

    • 1-a Data from Bores et al. (1996).

    • 1-b Data from Camara et al. (1997).

    • 1-c Data from Ogura et al. (2000).