Table 1

The potency (pEC₅₀) of glutamate for Ca²⁺ mobilization and [³H]IP formation in L929sA cells expressing the hmGlu1a receptor after preincubation of the cells with increasing concentrations of CPCCOEt or (S)-4C3HPG

Antagonist Concentration	Glutamate (pEC₅₀)
Antagonist Concentration	Ca²⁺Mobilization	[³H]IP Formation
CPCCOEt
0	4.8 ± 0.2	4.6 ± 0.2
1 μM	5.1 ± 0.2	4.5 ± 0.5
10 μM	5.3 ± 0.1^1-150	4.9 ± 0.1
100 μM	5.4 ± 0.1^1-160	5.1 ± 0.2^1-150
(S)-4C3HPG
0	4.8 ± 0.2	4.8 ± 0.3
1 μM	5.1 ± 0.1	4.9 ± 0.3
10 μM	5.2 ± 0.1^1-150	4.8 ± 0.5
100 μM	5.2 ± 0.1^1-150	5.2 ± 0.2^1-150

Values shown are mean ± S.D. of three experiments. Statistical analysis was performed using the Student's t test (two-tailed).

↵1-150 p < 0.05;
↵1-160 p < 0.01.