Line (NSE-tTA × TetOp-CREB) | Striatum | Nucleus Accumbens | Cortex | Hippocampus | Cerebellum |
---|---|---|---|---|---|
CREB6-A | +++ | ++ | + | − | − |
CREB6-B | +++ + | +++ | − | − | + |
CREB3-A | ++ | + | − | + | − |
Level of CREB overexpression is indicated by the number of + symbols. Overexpression of CREB in cerebellum was confirmed by Western blotting (see text).