Table 3

CYP3A phenotype as a function of CYP3A5 genotype

All GenotypesCYP3A53-1501/3-1501CYP3A53-1501/3-1503CYP3A53-1503/3-1503
Liver microsomal protein(n  =  60)(n  =  1)(n  =  13)(n  =  36)
 CYP3A5 (pmol/mg)3.0  (0.25–291)291 70.6  (22.2–164)2.5  (0.25–6.6)3-160
 CYP3A4 (pmol/mg)58.4  (5–376)  90.171.6  (5–187)57.8  (5–376)
 Total CYP3A (pmol/mg)70.4  (5.6–381)381 142  (27.2–351)59.7  (5.6–379)3-150
Jejunal homogenate protein(n  =  31)(n  =  2)(n  =  2)(n  =  27)
 CYP3A5 (pmol/mg)0.5  (0–19.8)14.0  (8.2,19.8)3.6  (2.6,4.5)0.5  (0–2.4)3-160
 CYP3A4 (pmol/mg)17.3  (0.5–32.8)17.2  (14.3,20.1)2.4  (0.9,3.8)18.2  (0.5–32.8)
 Total CYP3A (pmol/mg)18.7  (0.5–34.1)31.2  (28.3,34.1)5.9  (5.4,6.4)18.7  (0.5–33.3)

Data are reported as median (range).

    • ↵3-150  p < 0.01 comparingCYP3A5*1 carriers and CYP3A5*3/*3individuals.

    • ↵3-160  p < 0.001 comparing CYP3A5*1carriers and CYP3A5*3/*3 individuals.