Table 1

Common MDR1 polymorphisms that change amino acids

Location		Polymorphic Variant	Heterozygous Frequency	Reference
Exon	Nucleotide	Polymorphic Variant	Heterozygous Frequency	Reference
			%
2	61	N21D	17.6	Hoffmeyer et al. (2000)
			11.2	Cascorbi et al. (2001)
			5.7	Decleves et al. (2000)
5	307	F103L	1.2	Hoffmeyer et al. (2000)
10	1107	G369P	0.2	Cascorbi et al. (2001)
11	1199	S400N	12.9	Hoffmeyer et al. (2000)
			5.5	Cascorbi et al. (2001)
		A893S	43.0	Mickley et al. (1998)
		A893T	41.6	Cascorbi et al. (2001)
21	2677	A893S	62.0^1-a, 13.0^1-b	Kim et al. (2001)
		A893G	56.4	Cascorbi et al. (2001)
24	2995	A998T	11.0	Mickley et al. (1998)