Table 1

AKAPs in the heart

AKAP	Location in Myocytes	Possible Binding Partners in Myocytes	References
AKAPs studied in relation to their cardiac function
mAKAP	Nuclear envelope	RyR, PP2A, PDE4D3	Kapiloff et al., 1999, 2001; Marx et al., 2000, 2001; Dodge et al., 2001
AKAP18/15	Plasma membrane	L-type Ca^2⁺ channels	Fraser et al., 1998; Gray et al., 1998; Hulme et al., 2001
Yotiao	Plasma membrane	KCNQ1 (KvLQT1) delayed rectifier potassium channel, PP1	Potet et al., 2001, Marx, 2002
?	Sarcomere	Troponin I, myosin binding protein C	Fink et al., 2001
?	SR	RyR	Kapiloff et al., 2001
AKAPs detected by RNA or protein analysis, but with no studies published regarding cardiac function
AKAP-lbc	Actin stress fibers	Rho, actin, Gα_12, Gα₁₃	Diviani et al., 2001
Gravin	Cytoskeleton	β₂-adrenergic receptor, calcineurin, protein kinase C	Fan et al., 2001
AKAP95	Nuclear matrix	p68 RNA helicase, DNA	Akileswaran et al., 2001
AKAP149/AKAP121/D-AKAP-1/S-AKAP84^1-a	Mitochondrion, SR, nuclear envelope	PP1, AMY-1 (c-myc binding protein)	Lin et al., 1995; Feliciello et al., 1998; Huang et al., 1999; Steen et al., 2000; Furusawa et al., 2001
Ezrin	Actin cytoskeleton	Multiple, including cystic fibrosis transmembrane conductance regulator (Cl⁻ channel) and RhoGDP dissociation inhibitor	Bretscher, 1999
AKAP220	Vesicles	PP1	Schillace and Scott, 1999

↵1-a Alternative splice forms. Proteins associated with these AKAPs in other tissues are not listed and are reviewed elsewhere (Colledge and Scott, 1999; Skalhegg and Tasken, 2000; Feliciello et al., 2001).