Compound | EC50(n) | Dex Efficacy |
---|---|---|
nM | % | |
A276575 | 10 ± 0.93 (8) | 88 ± 3.5 (8) |
(−)-Syn enantiomer | 12 ± 3.0 (8) | 90 ± 2.0 (8) |
(+)-Syn enantiomer | 84 ± 19 (7) | 86 ± 2.2 (7) |
(−)-Anti enantiomer | 20 ± 6.5 (6) | 97 ± 0.66 (6) |
(+)-Anti enantiomer | 180 ± 47 (5) | 84 ± 2.4 (5) |
Dexamethasone | 1.4 ± 0.11 (5) | 100 (5) |
Values were the average ± S.E.M. of the number of experiments in parentheses conducted in duplicate. In the absence of IL-1β , the amount of IL-6 was between 19 and 118 pg/ml, and IL-1β (1 ng/ml) treatment, without test compounds, raised the levels to 4,173–49,000 pg/ml. The range of test compounds was 10 pM to 10 μM.