Repression activities of A276575 and its four enantiomers on ConA-induced proliferation of nontransfected human PBMC
| Compound | EC50(n) | Dex Efficacy |
|---|---|---|
| nM | % | |
| A276575 | 23 ± 15(4) | 87 ± 2.7 (4) |
| (−)-Syn enantiomer | 15 (2) | 76 (2) |
| (+)-Syn enantiomer | 180 ± 69 (3) | 100 ± 4.6 (3) |
| (−)-Anti enantiomer | 12 ± 3.6 (5) | 93 ± 1.7 (5) |
| (+)-Anti enantiomer | 450 ± 200 (3) | 88 ± 1.9 (3) |
| Dexamethasone | 1.5 ± 0.19 (5) | 100 (5) |
Values represent the average ± S.E.M. of the number of experiments in parentheses conducted in duplicate. The amount of [3H]thymidine was 10 to 91 and 3,750 to 11,000 dpm/well in the absence and presence of ConA, respectively. The range of test compounds was between 10 pM and 10 μM.