Effects of Dexamethasone, A276575, and its four enantiomers on aromatase activity in nontransfected primary human skin fibroblasts
| Aromatase | ||
|---|---|---|
| Compound | EC50 | Dex Efficacy |
| nM | % | |
| A276575 | 13 ± 9 | 74 ± 19 (4) |
| (−)-Syn enantiomer | 15 ± 5 | 80 ± 125-150 (3) |
| (+)-Syn enantiomer | 180 ± 45 | 61 ± 16 (3) |
| (−)-Anti enantiomer | 82 ± 35 | 82 ± 13 (4) |
| (+)-Anti enantiomer | 1200 ± 610 | 56 ± 105-150 (3) |
| Dexamethasone | 4 ± 1.1 | 100 (6) |
Values represent the mean ± S.E.M. of the number of experiments in parentheses conducted in duplicate. The amount of radioactivity incorporated into androgen in the presence and absence of Dex was 1190 to 1878 and 100 to 265 dpm/well, respectively.
↵5-150 P < 0.05 versus Dex, unpaired Student&rquote;s t test.