Table 2

Summary of NR effects on CAR signaling

NR	Binding to NR1	Activation of NR1/PBREM	Suppression of NR1/PBREM	Hepatic NR level in Rodents	Predicted Relevance of CAR Cross-Talk in Vivo
CAR	^2-219	^2-219 ⁺/^2-219 ⁺	N.A.	High	N.A.
PXR	⁺⁺	⁺⁺/⁺	⁺⁺/⁺⁺ ^{^2-b}	Moderate	^2-219 ⁺ Human, ⁺⁺ Mouse
VDR	^2-219 ⁺	⁺⁺/⁺	^2-219/⁺ ^{^2-b}	Low	⁺⁺ Human, 0 Mouse
TRα	^2-219 ⁺	⁺⁺/⁺	^2-219/⁺	Moderate	⁺ Human, 0 Mouse
PPARα	0	0/0	⁺⁺/⁺	High^2-c	⁺ Human, ⁺⁺Mouse
FXR	0	0/0	⁺⁺/⁺⁺	High	⁺⁺
COUP-TFI	⁺	–/–^2-a	^2-219 ⁺/^2-219 ^b	Low	⁺⁺
RARα	⁺	⁺/0	⁺/⁺	Low	0
LXRβ	⁺	0/0	0/0	Low	0

↵2-219 +, Strong effect; +++, significant effect; ++, moderate effect; +, weak effect; 0, no effect; N.A., not applicable.
↵2-a COUP-TFI represses NR1 and PBREM.
↵2-b PXR, VDR, and COUP-TFI suppress hPBREM more than mPBREM.
↵2-c Hepatic expression of hPPARα is significantly lower than that of mPPARα.