Open durations of mutant AChRs
| Mutant Subunit | Mean Open Time | n |
|---|---|---|
| ms | ||
| Wild-type | 0.90 ± 0.14 | 6 |
| αF8′I | 1.75 ± 0.30 | 8 |
| βL8′F | 0.30 ± 0.05 | 5 |
| δL8′F | 0.40 ± 0.07 | 8 |
| ɛV8′F | 0.45 ± 0.14 | 6 |
Recordings were obtained from cells expressing AChRs containing the indicated mutant subunit and activated by 1 μM ACh. The mean open times were obtained from the corresponding open-time histograms.n is the number of recordings for each condition.