Effects of rifampicin (RIF) and PB on expression of genes in primary cultures of human hepatocytes derived from two donors. Data represent fold activation relative to treatment with vehicle alone.
| Donor 1 | Donor 2 | |||
|---|---|---|---|---|
| Gene | RIF | PB | RIF | PB |
| 1 ALDH1A1 | 2.7 | 3.2 | 1.6 | 2.1 |
| 2 CYP1A1 | 27 | 1.3 | 15 | 5.9 |
| 3 CYP1A2 | 26 | 1.7 | 3.2 | 1.8 |
| 4 CYP1B1 | 1.6 | N.C. | 1.7 | N.C. |
| 5 CYP2A6 | N.C. | 1.7 | 2.5 | 5.2 |
| 6 CYP2B6 | 4.9 | 9.5 | 8.4 | 4.5 |
| 7 CYP3A4 | 5.7 | 4.9 | 4.6 | 2.9 |
| 8 GSTA2 | 23 | 18 | 4.7 | 2.1 |
| 9 MDR1 | 7.5 | 13 | 3.0 | 3.4 |
| 10 SULT1A1 | 3.0 | 3.6 | N.C. | N.C. |
| 11 ALAS1 | 9.8 | 9.2 | 5.5 | 9.6 |
| 12 AhR | 2.6 | 3.8 | 2.1 | 1.9 |
| 13 POR | N.C. | 1.5 | 2.2 | 2.9 |
| 14 CAR | N.C. | N.C. | N.C. | N.C. |
| 15 PXR | N.C. | N.C. | 1.5 | 2.0 |
N.C., no change.