Effects of VDM13 (50 μM) on responses to vanilloid receptor agonists in guinea pig mesenteric arteries (MA) and main bronchi (MB)
| Agonist | Mesenteric Arteries | Main Bronchi | EC50 ratio | ||||
|---|---|---|---|---|---|---|---|
| n | Emax | pEC50 | n | Emax | pEC50 | (MB/MA) | |
| Anandamide | 7 | 98 ± 1 | 6.0 ± 0.1 | 4 | >49 ± 6 | <5.2 ± 0.1 | >8.3 |
| + VDM13 | 7 | 91 ± 3 | 5.7 ± 0.1a | 4 | >32 ± 10 | <5.2 ± 0.1 | >3.4 |
| Capsaicin | 4 | 96 ± 2 | 8.3 ± 0.2 | 4 | 94 ± 5 | 8.1 ± 0.1 | 1.5 |
| + VDM13 | 5 | 96 ± 2 | 8.3 ± 0.1 | 4 | 92 ± 5 | 8.0 ± 0.1 | 1.7 |
| Resiniferatoxin | 5 | 95 ± 2 | 10.5 ± 0.1 | 4 | 76 ± 6 | 9.4 ± 0.1 | 16 |
| + VDM13 | 5 | 90 ± 6 | 10.3 ± 0.1 | 4 | 67 ± 3 | 9.2 ± 0.1 | 11 |
| Olvanil | 6 | 97 ± 2 | 8.4 ± 0.1 | 5 | >67 ± 8 | <5.4 ± 0.1 | >1030 |
| + VDM13 | 5 | 94 ± 3 | 6.2 ± 0.2b | 5 | >53 ± 5 | <5.5 ± 0.1 | >5.5 |
Values are expressed as mean ± S.E.M.
a P < 0.01, VDM13 versus vehicle.
b P < 0.001, VDM13 versus vehicle.