Genes specifically modified in mouse brain 12 h after R(+)-WIN 55,212-2 administration
| Gene Name | Symbol | E | GenBank Accession No. | Fold Change |
|---|---|---|---|---|
| Down-regulated genes | ||||
| Protein processing | ||||
| Protein folding | ||||
| Chaperonin containing TCP-1β | Ccth | 0 | AB022160 | −2.6 |
| Ubiquitin-protein Ligase | ||||
| Neural precursor developmentally down-regulated 4b | Nedd4b | 0 | NM031881 | −2.1 |
| Neuronal signaling | ||||
| Synaptic endocytosis | ||||
| Protein kinase C and casein kinase substrate in neurons | Pacsin1 | 1e−110 | NM011861 | −2.1 |
| Control of cell proliferation and differentiation | ||||
| Protein tyrosine phosphatase receptor | Ptprn | 0 | NM008985 | −2.1 |
| Expressed sequence tags | ||||
| Clone MGC:7904 | 0 | BC004732 | −2.2 | |
| Highly similar to KIAA0893 protein | 2e−96 | NM014969 | −2.0 | |
| Clone MGC:7410 | 0 | BC003968 | −3.0 | |
| Up-regulated genes | ||||
| Protein processing | ||||
| Protein folding | ||||
| Heat shock 27 kDa protein 3 | Hspb3 | 0 | NM019960 | +2.4 |
| Neuronal signaling | ||||
| Control of cell proliferation and differentiation | ||||
| Cyclin-dependent protein kinase 1 | PFTK1 | 4e−40 | NM012395 | +2.0 |
| Endothelial differentiation G-protein receptor 3 | Edg3 | 1e−157 | NM10101 | +2.2 |
| Control of signal transduction | ||||
| TNF receptor-associated factor 5 | Traf5 | 0 | NM011633 | +2.2 |
| Neuronal growth/structure | ||||
| Netrin 1 | Ntn1 | 0 | NM00874 | +2.2 |
| Microtubule-associated protein tau | Mapt | 1e−105 | NM010838 | +2.6 |
| Stress response | ||||
| DNA damage-induced apoptosis | ||||
| Myelocytomatosis oncogene | Myc | 0 | NM010849 | +2.1 |
| DNA replication and repair | ||||
| Replication factor C, 140 kDa | Recc1 | 0 | NM011258 | +2.9 |
| Others | ||||
| Down syndrome critical region a, clone MGC:5833 | 0 | BC003740 | +2.7 |
Expression levels are ratios of R(+)-WIN 55,212-2-treated versus control samples. Each mRNA sample group was hybridized to three different arrays, and fold-change values are average of the triplicate measurements. Matches of clone sequences from cDNA arrays were based on the closest calculated expect value (E).
TNF, tumor necrosis factor; TCP-1β, t-complex polypeptide-1β.