Gene Name | Symbol | E | GenBank Accession No. | Fold Change |
---|---|---|---|---|
Down-regulated genes | ||||
Protein processing | ||||
Protein folding | ||||
Chaperonin containing TCP-1β | Ccth | 0 | AB022160 | −2.6 |
Ubiquitin-protein Ligase | ||||
Neural precursor developmentally down-regulated 4b | Nedd4b | 0 | NM031881 | −2.1 |
Neuronal signaling | ||||
Synaptic endocytosis | ||||
Protein kinase C and casein kinase substrate in neurons | Pacsin1 | 1e−110 | NM011861 | −2.1 |
Control of cell proliferation and differentiation | ||||
Protein tyrosine phosphatase receptor | Ptprn | 0 | NM008985 | −2.1 |
Expressed sequence tags | ||||
Clone MGC:7904 | 0 | BC004732 | −2.2 | |
Highly similar to KIAA0893 protein | 2e−96 | NM014969 | −2.0 | |
Clone MGC:7410 | 0 | BC003968 | −3.0 | |
Up-regulated genes | ||||
Protein processing | ||||
Protein folding | ||||
Heat shock 27 kDa protein 3 | Hspb3 | 0 | NM019960 | +2.4 |
Neuronal signaling | ||||
Control of cell proliferation and differentiation | ||||
Cyclin-dependent protein kinase 1 | PFTK1 | 4e−40 | NM012395 | +2.0 |
Endothelial differentiation G-protein receptor 3 | Edg3 | 1e−157 | NM10101 | +2.2 |
Control of signal transduction | ||||
TNF receptor-associated factor 5 | Traf5 | 0 | NM011633 | +2.2 |
Neuronal growth/structure | ||||
Netrin 1 | Ntn1 | 0 | NM00874 | +2.2 |
Microtubule-associated protein tau | Mapt | 1e−105 | NM010838 | +2.6 |
Stress response | ||||
DNA damage-induced apoptosis | ||||
Myelocytomatosis oncogene | Myc | 0 | NM010849 | +2.1 |
DNA replication and repair | ||||
Replication factor C, 140 kDa | Recc1 | 0 | NM011258 | +2.9 |
Others | ||||
Down syndrome critical region a, clone MGC:5833 | 0 | BC003740 | +2.7 |
Expression levels are ratios of R(+)-WIN 55,212-2-treated versus control samples. Each mRNA sample group was hybridized to three different arrays, and fold-change values are average of the triplicate measurements. Matches of clone sequences from cDNA arrays were based on the closest calculated expect value (E).
TNF, tumor necrosis factor; TCP-1β, t-complex polypeptide-1β.