Genes modified in mouse brain 12 h after both Δ9-THC and R(+)-WIN 55,212-2 administration
| Gene Name | Symbol | E | GenBank Accession No. | Fold change (WIN) | Fold change (THC) |
|---|---|---|---|---|---|
| Down-regulated genes | |||||
| Myelination/glial differentiation | |||||
| ATP-binding cassette subfamily A, member 2 | ABC2 | e−152 | X75927 | −2.1 | −3.1 |
| Neuronal signaling | |||||
| Control of signal transduction | |||||
| Protein phosphatase 2A, α isoform | Ppp2r1a | e−114 | NM016891 | −2.2 | −2.9 |
| Embryonal Fyn-associated substrate | Efyn | e−133 | BC005438 | −2.1 | −2.3 |
| Prostaglandin D synthetase | PGD | 0 | X89222 | −2.1 | −2.1 |
| Control of cell proliferation and differentiation | |||||
| Survival motor neuron | SMN | e−162 | Y12835 | −2.1 | −2.9 |
| Mortality factor-regulator gene 15 | MRG15 | e−153 | AB042241 | −2.2 | −2.9 |
| N-myc downstream-regulated gene 4 | NDRG4 | e−108 | BC006595 | −2.6 | −2.8 |
| Reticulon 3 | RTN3 | e−152 | AF195940 | −2.2 | −2.6 |
| Neuronal growth/structure | |||||
| Microtubule-associated protein 2 | Mtap2 | e−126 | NM008632 | −2.2 | −3.1 |
| Protease nexin-1 | PN-1 | e−137 | NM009255 | −2.1 | −2.5 |
| Neuronal protein 25 | Np25 | e−107 | NM019754 | −2.2 | −2.4 |
| Expressed sequence tags | |||||
| Clone MGC:6545 | e−153 | BC003451 | −2.1 | −2.3 | |
| Up-regulated genes | |||||
| Metabolic enzymes | |||||
| Glucokinase | GK | e−153 | L38990 | +2.0 | +2.0 |
| Neuronal signaling | |||||
| Control of signal transduction | |||||
| Gioblastoma-expressed ring finger protein | GERP | e−166 | AF281047 | +2.4 | +2.3 |
| Transcription factor | |||||
| Melanocyte-specific gene-related gene 1 | MRG1 | 0 | Y15163 | +2.3 | +2.0 |
| Stress Response | |||||
| Apoptosis-induced gene | |||||
| P53 apoptosis effector related to Pmp22 | Perp | 0 | NM022032 | +2.8 | +2.2 |
| Expressed sequence tags | |||||
| Clone MGC:12127 | 0 | BC006765 | +2.7 | +2.2 |
Expression levels are ratios of R(+)-WIN 55,212-2- or Δ9-THC-treated versus control samples. Each mRNA sample group was hybridized to three different arrays, and fold-change values are average of the triplicate measurements. Matches of clone sequences from cDNA arrays were based on the closest calculated expect value (E).