Table 1

Antagonist activity and membrane/buffer partition coefficient for a series of alcohols and a nonvolatile anesthetic. Cell adhesion assays were performed in the absence and presence of the indicated compounds, as described in the text. Antagonist activity was measured against 100 mM ethanol for all of the compounds or against 2 mM 1-butanol, where indicated. The aqueous concentration of each antagonist was calculated to produce membrane concentrations equivalent to 100 mM ethanol. Membrane/buffer partition coefficients (P_m/b) were obtained or calculated from published octanol/water partition coefficients. The compounds are sorted by decreasing membrane/buffer partition coefficients. The P_m/b for ethanol is 0.096 and for 1-butanol is 1.52.