Pharmacological selectivity of [3H]MRS2279 binding in P2Y1-Sf9 membranes
| Antagonist | Ki (n = 3–5) | KB | Reference |
|---|---|---|---|
| nM | nM | ||
| MRS2279 | 13 ± 3 | 8 | Boyer et al. (2002) |
| MRS2179 | 84 ± 27 | 102 | Boyer et al. (1998) |
| A3′P5′P | 1,500 ± 400 | 900 | Boyer et al. (1996a) |
| PPADS | 6,200 ± 2,600 | 1200 | Boyer et al. (1994) |
| Suramin | 4,900 ± 1,600 |
| Agonist | IC50 (n = 3–6) |
|---|---|
| nM | |
| 2MeSADP | 106 ± 51 |
| 2MeSATP | 112 ± 25 |
| ADP | 643 ± 79 |
| ATP | 777 ± 350 |
| ATPγS | 3,200 ± 1,700 |
ATPγS, adenosine-5′-O-(3-thio)triphosphate.