The lack of agonist-specific desensitization of chimeric P2X2aR and P2X2bR containing the extracellular domain of P2X3Rs
| Agonist | P2X2a+X3EC | P2X2b+X3EC |
|---|---|---|
| s−1 | ||
| ATP, 1 μM | 0.0188 ± 0.0012 (5) | 0.0609 ± 0.00696 (8)1-150 |
| ATP, 10 μM | 0.0172 ± 0.0013 (5) | 0.0598 ± 0.00375 (5)1-150 |
| αβ-meATP, 1 μM | 0.0193 ± 0.0014 (4) | 0.0614 ± 0.0024 (4)1-150 |
| BzATP, 1 μM | 0.0143 ± 0.0011 (7) | 0.0660 ± 0.0055 (10)1-150 |
| BzATP, 10 μM | 0.0187 ± 0.0015 (11) | 0.0674 ± 0.0079 (7)1-150 |
| BzATP, 100 μM | 0.0183 ± 0.0011 (9) | 0.0609 ± 0.0057 (5)1-150 |
Data shown are means ± S.E.M. for rates of inactivation of two chimeric receptors. Numbers in brackets indicate number of experiments, each performed in at least 15 cells.
↵1-150 , P < 0.05.