Inhibition of soft agar colony formation by lung cancer cells
| IC50 | ||
|---|---|---|
| Cell Line | Sulindac Sulfide | Indomethacin |
| μM | ||
| NSCLC | ||
| H2122 | 20 | 27 |
| A549 | 80 | >100 |
| H460 | 29 | 40 |
| SCLC | ||
| SHP-77 | 8 | 5 |
| H345 | 20 | 18 |
Replicate plates of the respective NSCLC or SCLC cell lines were plated in soft agar at 10,000 cells per well in the presence of various concentrations of sulindac sulfide or indomethacin. Colonies were counted after 3 weeks and the IC50 values were calculated.