Effects of various chronic treatments on PRAX-1 mRNA in the hippocampus
| Dentate Gyrus Granule cell layer | CA1 Pyramidal cell layer | CA3 Pyramidal cell layer | |
|---|---|---|---|
| % | |||
| Saline | 100 ± 3 | 100 ± 9 | 100 ± 11 |
| Fluoxetine | 149 ± 121-150 | 173 ± 251-150 | 90 ± 7 |
| Imipramine | 155 ± 81-150 | 214 ± 111-150 | 93 ± 5 |
| Iproniazid | 119 ± 7 | 157 ± 181-150 | 136 ± 121-150 |
| Tranylcypromine | 118 ± 71-150 | 186 ± 171-150 | 83 ± 8 |
| Haloperidol | 119 ± 21-150 | 101 ± 7 | 101 ± 6 |
| Diazepam | 103 ± 5 | 93 ± 9 | 83 ± 13 |
| SR48968 | 161 ± 81-150 | 150 ± 111-150 | 103 ± 5 |
Rats were administered imipramine, iproniazid, tranylcypromine, haloperidol, diazepam, SR48968, or saline for 21 days and subjected to in situ hybridization analysis using 35S-labeled PRAX-1 riboprobes. Quantification of PRAX-1 mRNA in the DG and CA1 and CA3 regions of the hippocampus was performed by optical densitometry. Values are expressed as percentage of saline and represent mean ± S.E.M., n = 4 to 5 rats per group.
↵1-150 , p < 0.05 versus saline-treated rats (Student's t test).