Amthamine | Forskolin | |||
---|---|---|---|---|
EC_{50} | R_{max} | EC_{50} | R_{max} | |
nM | pmol/10^{6}cells | mM | pmol/10^{6}cells | |
U-937 | 465 ± 95 (5) | 184 ± 35 (5) | 161 ± 42 (3) | 120 ± 27 (3) |
D2 | 562 ± 97 (3) | 143 ± 26 (3) | N.D. | N.D. |
A2 | 426 ± 47 (3) | 281 ± 67 (3)^{1-150} | N.D. | N.D. |
D5 | 472 ± 67 (3) | 292 ± 38 (3)^{1-150} | 121 ± 37 (3) | 116 ± 22 (3) |
H3 | 584 ± 78 (3) | 142 ± 27 (3) | N.D. | N.D. |
EC_{50 }and maximal response (R _{max}) were calculated from the data in Fig. 3 using the equation for dose-response curves. The table shows the mean ± S.E.M.; the number of determinations (n) is in parentheses. TheR _{max} of amthamine for the different clones with respect to U-937 were compared using an unpaired t test, and D5 and A2 clones were found to be significantly different.
N.D., not determined.
↵1-150 , p < 0.01.