Compound | TK-2 | HSV-1 TK | Dm-dNK | |||
---|---|---|---|---|---|---|
Ki | Ki/Km | Ki | Ki/Km | Ki | Ki/Km | |
μM | μM | μM | ||||
KIN-5 | 22 ± 5 | 20 | 3.3 ± 0.5 | 2.6 | 10 ± 5 | 4.3 |
KIN-6 | 13 ± 3 | 10 | 6.1 ± 0.8 | 3.7 | 15 ± 2 | 2.8 |
KIN-12 | 0.78 ± 0.08 | 0.65 | 16 ± 0.8 | 11 | 1.7 ± 0.2 | 0.57 |
KIN-39 | 3.1 ± 0.1 | 3.0 | 0.46 ± 0.19 | 0.25 | 7.1 ± 2.5 | 1.7 |
KIN-52 | 0.50 ± 0.03 | 0.37 | N.A. | N.A. | ||
BVDU | 0.22 ± 0.02 | 0.14 | 0.29 ± 0.10 | 0.10 | 0.64 ± 0.04 | 0.50 |
Ki values derived from Lineweaver-Burk plots. Data are derived from two to three independent experiments.Km values for dThd are 1.17 ± 0.11 μM (TK-2), 1.52 ± 0.23 μM (HSV-1 TK), and 3.64 ± 1.27 μM Dm-dNK.
N.A., not applicable: no measurable inhibition.