Effects of alanine mutations in domains III and IV S6 segments of the L-type Ca2+ channel on binding of isradipine ((+)-[3H]PN200–110)
| IIIS6 Mutation | Mutant IC50/Native IC50 | IVS6 Mutation | Mutant IC50 /Native IC50 |
|---|---|---|---|
| Y1152A | 25 | Y1463A | 2.9 |
| (Y1152F) | 12.4 | M1464A | 1.6 |
| I1153A | 6.2 | I1471A | 2.7 |
| I1156A | 17 | N1472A | 8.9 |
| F1159A | 4.5 | ||
| M1160A | 3.5 | ||
| M1161A | 9.6 |
Data from Peterson et al. (1997).