Table 1
Chemical structures and physicochemical properties
| Compound | Structure | M.W. (free base) | Log P | pKa | Ionization (mol%, pH 7.4) |
|---|---|---|---|---|---|
| Clenbuterol | 277.19 | 2.612 ± 0.382 | 13.29 ± 0.20 | >99.9 | |
| Salbutamol | 239.31 | 0.015 ± 0.301 | 9.83 ± 0.20 | 99.6 | |
| Propranolol | 259.34 | 3.097 ± 0.193 | 13.84 ± 0.20 | >99.9 | |
| Nadolol | 309.40 | 1.288 ± 0.344 | 13.91 ± 0.2 | >99.9 | |
| Mexiletine | 179.26 | 2.160 ± 0.228 | 8.58 ± 0.20 | 93.4 | |
pK a and ionization refer to the amine group of the drugs. Log P and pK a were calculated using Advanced Chemistry Development Software Solaris v4.67; ionization was calculated from Henderson-Hasselbalch equation.