List of affected genes from two-component analysis
| DHEA vs. Untreated | Fold Change | Nafenopin vs. Untreated | Fold Change |
|---|---|---|---|
| Gene expression known to be affected by treatment with peroxisome proliferators | Gene expression known to be affected by treatment with peroxisome proliferators | ||
| Cytochrome P540 4A1 | 60.6 | Cytochrome P450 4A1 | 59.2 |
| Cytochrome P450 4A3 | 23.7 | Cytochrome P450 4A3 | 44.3 |
| Acyl-CoA oxidase | 11.1 | Acyl-CoA oxidase | 9.1 |
| Fatty acid transport protein | 8.1 | Fatty acid transport protein | 11.3 |
| NADPH-cytochrome P450 reductase | 7.8 | NADPH-cytochrome P450-oxidoreductase | 5.9 |
| 3-Keto-CoA thiolase2-150 | 4.3 | 3-Keto-CoA thiolase | 10.1 |
| Cytochrome P450 2C11 | −5.2 | Cytochrome P450 2C112-150 | −3.8 |
| Corticosteroid 11-β-dehydrogenase 1 | −7.9 | Corticosteroid 11-β-dehydrogenase 12-150 | −4.2 |
| Apolipoprotein A–IV | −8.9 | Apolipoprotein A–IV | −4.6 |
| Additional genes - expression affected by DHEA and nafenopin treatment | Additional genes - expression affected by DHEA and nafenopin treatment | ||
| Acetylcholine receptor, nicotinic, α4 | 9.4 | Acetylcholine receptor, nicotinic, α4 | 13.1 |
| Androgen binding protein | 9.1 | Androgen binding protein | 8.8 |
| Arrestin D + guanine aminohydrolase | 8.8 | Arrestin D + guanine aminohydrolase | 9.0 |
| Antigen peptide transporter 2 | 6.6 | Antigen peptide transporter 2 | 5.5 |
| Liver carboxylesterase 10 | 5.2 | Liver carboxylesterase 102-150 | 4.3 |
| Insulin-like growth factor binding protein 1 | 4.9 | Insulin-like growth factor binding protein 12-150 | 3.1 |
| Cytochrome P450 17 | 4.6 | Cytochrome P450 17 | 5.3 |
| Mitochondrial carnitineO-palmitoyltransferase I2-150 | 4.2 | Mitochondrial carnitine O-palmitoyltransferase I | 4.7 |
| HSP84; HSP90-β2-150 | 3.6 | HSP84; HSP90-β | 4.6 |
| Plasma membrane Ca + 2 ATPase | −5.2 | Plasma membrane Ca + 2 ATPase | −5.0 |
| Gene expression affected by DHEA- more than nafenopin-treatment | Gene expression affected by nafenopin more than DHEA treatment | ||
| Aquaporin 3 | 8.5 | Bile-salt-activated lipase | 74.7 |
| Nuclear tyrosine phosphatase | 6.3 | Trypsinogen II | 40.9 |
| A-raf | −4.8 | Triacylglycerol lipase | 17.4 |
| β2-microglobulin | −11.5 | Chymotrypsinogen B | 16.6 |
| Elastase 2 | 12.7 | ||
| Phospholipase A2 | 11.0 | ||
| Colipase | 7.1 | ||
| P55cdc: cdc20 | 6.8 | ||
| Serum/glucocorticoid-regulated Ser/Thr protein kinase | −6.6 |
↵2-150 Variation at the 99% confidence interval with only DHEA treatment or nafenopin treatment, but not both.