Patient | Age | Gender | Time to Reaction | Details of Reaction | Time Since Reaction | Rechallenge |
---|---|---|---|---|---|---|
years | days | months | ||||
1 | 69 | Male | 21 | Widespread maculopapular eruption with tissue eosinophilia | 16 | No |
2 | 65 | Female | 42 | Maculopapular eruption, fever, eosinophilia, abnormal liver function tests | 72 | No |
3 | 65 | Female | 1 (rechallenge) | Desquamating rash with fever on inadvertent rechallenge; history of rash on initial exposure | <11-a | Positive |
4 | 27 | Female | 1 | Widespread maculopapular rash with mild fever and eosinophilia after one dose; history of allergy to multiple antibiotics and possible exposure to carbamazepine in the past with development of rash | 2 | Previous exposure likely |
5 | 26 | Male | 21 | Widespread rash with fever; history of allergy to multiple drugs including lamotrigine and phenytoin | 24 | No |
↵1-a The time blood was taken after rechallenge with CBZ.