Biguanide Compounds | Metformin | Buformin | Phenformin |
---|---|---|---|
EC50(μ M) | 734 ± 168 | 119 ± 18 | 4.97 ± 0.87 |
Blood lactate concentration was determined after the administration of biguanides at five different doses by constant intravenous infusion. The EC50 was calculated from the increase in lactate AUC and steady-state unbound plasma concentration of biguanides.