Table 5

Equilibrium binding constants of [3H]R214127 binding to membranes from rat cortex, hippocampus, striatum, and cerebellum

CortexHippocampusStriatumCerebellum
K D(nM)1.04  ± 0.400.72  ± 0.220.84  ± 0.230.99  ± 0.36
B max(fmol/mg of protein)471  ± 68688  ± 125741  ± 484302  ± 2042

KD and Bmax values are mean ± S.D. derived from three independent experiments.