| |
mV
|
mV
|
ms
| μM | |
Kv2.1 | 10 | +7 ± 0.9 | ±0 | 12.0 ± 1 | 220 ± 30 | 0.44 ± 0.07 |
Kv1.2 | 12 | -13 ± 0.9 | -22 | 3.7 ± 0.3 | 210 ± 20 | 0.00 ± 0.07 |
S6 Modifications | | | | | | |
ChS6 | 5 | -29 ± 2 | -36 | 7.7 ± 0.4 | 520 ± 50 | 0.03 ± 0.08 |
Mu395 | 5 | +6 ± 4 | -1 | 6.6 ± 0.4 | 220 ± 50 | 0.05 ± 0.05 |
Mu404 | 5 | +11 ± 6 | +4 | 5.1 ± 0.2 | 420 ± 40 | 0.51 ± 0.10 |
Mu409 | 5 | +16 ± 1 | +9 | 6.1 ± 0.6 | 330 ± 60 | 0.47 ± 0.07 |
Mu417 | 6 | -4 ± 2 | -1 | 11.4 ± 0.7 | 170 ± 20 | 0.56 ± 0.08 |
S5-S6 Linker Modifications | | | | | | |
ChS5-S6 | 5 | +14 ± 1 | +7 | 7.9 ± 1.1 | 1150 ± 60 | 0.35 ± 0.07 |
External Residues | | | | | | |
MuS5-P | 5 | +8 ± 3 | +1 | 11.7 ± 1.6 | 180 ± 50 | 0.52 ± 0.10 |
MuP-S6 | 4 | +2 ± 3 | -5 | 7.2 ± 2.0 | 500 ± 40 | 0.52 ± 0.09 |
MuS5-P/P-S6 | 5 | +8 ± 1 | +1 | 9.4 ± 0.7 | 360 ± 50 | 0.45 ± 0.08 |
Pore-loop Residues | | | | | | |
Mu366 | 3 | +3 ± 0.5 | +4 | 7.2 ± 0.8 | 640 ± 40 | 0.50 ± 0.06 |
Mu372 | 6 | +12 ± 2 | +5 | 10.5 ± 1.4 | 1170 ± 30 | 0.46 ± 0.09 |
Mu383 | 3 | +5 ± 1 | -2 | 15.1 ± 2.1 | 330 ± 40 | 0.28 ± 0.05 |