[3H]dimethyl-W84 | [3H]NMS | logKX,orthoster - logKi,orthoster | |||
---|---|---|---|---|---|
Orthosteric agent | logKX,orthoster | α | logKi,orthoster | nH | |
(+)-Dexetimide | 9.03±0.07 | 0.02±0.03 | 8.93±0.19 | 1.07±0.08 | 0.10 |
NMS | 9.40±0.12 | 0.19±0.03 | 9.37±0.16a | 1.01±0.05 | 0.03 |
(-)-Scopolamine | 8.63±0.12 | 0.08±0.01 | 8.59±0.19 | 1.01±0.08 | 0.04 |
Atropine | 8.36±0.07 | 0.20±0.02 | 8.66±0.20 | 1.01±0.08 | -0.30 |
AF-DX 384 | 8.03±0.06 | 0.09±0.02 | 8.09±0.26 | 0.96±0.13 | -0.06 |
NBS | 6.77±0.07 | 0.07±0.02 | 6.78±0.20 | 1.04±0.08 | -0.01 |
(-)-Levetimide | 5.18±0.04b | —b | 5.32±0.17 | 1.02±0.08 | N.D. |