AUC values for PAS and SMZ elimination
AUC values (mean ± S.D., n = 3) were determined by the trapezoidal rule using Prism software. PAS or SMZ (50 mg/kg) was dosed by i.p. injection to age- and sex-matched wild-type and knockout mice. Four sequential blood samples were drawn and analyzed for parent and metabolite compounds as described under Materials and Methods.
| Genotype | PAS | AcPAS | SMZ | AcSMZ |
|---|---|---|---|---|
| mmol min/l | ||||
| Male +/+ | 5.4±3.5*** | 6.5±3.9* | 371±49 | 75+12*** |
| Male -/- | 18.5±2.5 | 0 | 519±195 | 0 |
| Female +/+ | 5.2±2.3*** | 7.4±3.0* | 404±137 | 43±14** |
| Female -/- | 12.9±1.8 | 0 | 572±170 | 0 |