TABLE 1

[³⁵S]GTPγS intrinsic efficacies (E_max), potencies (EC₅₀), and relative E_max of DAMGO and BUP in DRG membranes of animals without (Control) and with (FCA) inflammation

Data are mean values ± S.E.M. of at least three independent experiments as described in Materials and Methods. E_max values are percentage stimulation over basal and relative E_max values are expressed as a percent of maximal stimulation with DAMGO in animals without inflammation.

	DAMGO			BUP
	EC₅₀	E_max	Relative E_max	EC₅₀	E_max	Relative E_max
	nM	%		nM	%
DRG_Control	56 ± 18	20 ± 0.9	100 ± 5.0	N.D.	N.D.	N.D.
DRG_FCA	29 ± 12	31 ± 1.9^*	148 ± 5.6^*	1.6 ± 0.4	16 ± 1.5	82 ± 4.2

N.D., not detected.
↵* P < 0.05 different from animals without inflammation.