Relative potency of nitrendipine for the block of ICa recorded by giving test pulses to 0 mV for 100 ms from a holding potential at −70 mV at 0.1 Hz
| IC50 | Fold Increase vs. rbCII | n | |
|---|---|---|---|
| μM | |||
| rbCII | 0.504 ± 0.141 | 3 | |
| F1112A | 2.58 ± 0.117 | 5.13 | 4 |
| S1115A | 19.9 ± 3.83* | 39.4 | 3 |
| F1112A/S1115A | 25.3 ± 3.20* | 50.2 | 4 |
↵* P < 0.01 versus rbCII.