TABLE 1

Correlation of proliferation parameters (cell doubling time and cell cycle phases) with the IC50 values for standard antineoplastic agents in the NCI cell line panel

Numbers are P values (Kendall's τ test).

Doubling Time G0/G1 S G2/M
Doxorubicin 0.01445 0.15533 0.17845 0.00371
Vinblastine 0.00248 0.46660 0.06903 0.01866
5-Fluorouracil <0.00001 0.46994 0.01889 0.06871
Methotrexate <0.00001 0.13427 0.00505 0.00936
Carboplatin 0.47414 0.14364 0.22549 0.11834
Dacarbazine 0.33905 0.32246 0.35002 0.14325
Ifosfamide 0.34686 0.41963 0.23635 0.38028