Drug Resistance Genes
| | | |
GLCLR
| Glutamate-cysteine ligase, regulatory (30.8 kD), γ-glutamylcysteine
synthetase
| 0.00051
| 0.30452
|
GSTT2
| Glutathione S-transferase T2
| 0.00136
| 0.27787
|
MGST3
| Microsomal glutathione S-transferase 3
| 0.00246
| 0.27144
|
TOP1
| DNA topoisomerase I
| 0.00001
| −0.38821
|
=4/63 genes (=6%)
| | | |
DNA Damage and Repair Genes
| | | |
ERCC5
| Excision repair cross-complementing rodent repair deficiency, complementation
group 5
| 0.00074
| −0.29471
|
UNG
| Uracil-DNA glycosylase
| 0.00116
| −0.28233
|
FEN1
| Flap structure-specific endonuclease 1
| 0.00014
| −0.33695
|
LIG1
| ATP-dependent DNA ligase I
| 0.00037
| −0.31290
|
RPS3
| Ribosomal protein S3
| <0.00001
| −0.41150
|
UBE2A
| Ubiquitin-conjugating enzyme E2A; RAD6 homolog
| 0.00236
| 0.26201
|
HMG1
| High-mobility group 1
| 0.00049
| −0.30555
|
HMG17
| High-mobility group 17
| 0.00085
| 0.29403
|
=8/54 genes (=15%)
| | | |
Oncogenes and Tumor Suppressor Genes
| | | |
BRCA2
| Breast cancer susceptibility gene 2
| 0.00094
| −0.28832
|
EGFR
| Epidermal growth factor receptor
| 0.00390
| 0.24678
|
EMP1
| Epithelial membrane protein 1
| 0.00457
| 0.24412
|
FOSL2
| FOS-like antigen-2
| 0.00166
| 0.27229
|
IRF4
| Interferon regulatory factor 4
| 0.00156
| −0.27402
|
MEN1
| Multiple endocrine neoplasia 1
| 0.00278
| −0.25719
|
MYB
| v-myb avian myeloblastosis viral oncogene homolog
| 0.00006
| −0.36127
|
MYC
| v-myc avian myelocytomatosis viral oncogene homolog
| 0.00002
| −0.38498
|
CSK
| c-src tyrosine kinase
| 0.00142
| −0.27672
|
TGFB2
| Tumor growth factor β2
| 0.00345
| 0.25816
|
FOSB
| FBJ murine osteosarcoma viral oncogene homolog B
| 0.00456
| 0.24187
|
BRAF
| v-raf murine sarcoma viral oncogene homolog B1
| 0.00031
| −0.32033
|
RAB2
| Member RAS oncogene family 2
| 0.00047
| 0.30686
|
RAN
| Member RAS oncogene family
| 0.00315
| −0.25330
|
ARHC
| RAS oncogene family member C
| 0.00004
| 0.36634
|
ARHE
| RAS oncogene family member E
| 0.00097
| 0.28755
|
=16/112 genes (=14%)
| | | |
Apoptosis-Regulating Genes
| | | |
LOC51272
| Locus 51272
| 0.00153
| 0.27457
|
CIDEB
| Cell death-inducing DFFA-like effector b
| 0.00022
| −0.32566
|
PDCD2
| Programmed cell death 2
| 0.00040
| −0.31118
|
BAG1
| BCL2-associated athanogene
| 0.00045
| −0.29123
|
BAG3
| BCL2-associated athanogene 3
| 0.00505
| 0.23856
|
MADD
| MAP-kinase activating death domain
| 0.00720
| −0.22917
|
=5/65 genes (=8%)
| | | |
Proliferation-Associated Genes
| | | |
DNL
| Dynein, cytoplasmic, light polypeptide
| 0.00039
| 0.31182
|
KIF5B
| Kinesin family member 5B
| 0.00005
| 0.36333
|
TUBB4
| β-Tubulin 4
| 0.00260
| 0.15057
|
LOC57018
| Cyclin L ania-6a
| 0.00558
| −0.23537
|
CDK8
| Cyclin-dependent kinase 8
| 0.00019
| −0.32938
|
CDKN3
| Cyclin-dependent kinase inhibitor 3
| 0.00262
| −0.26151
|
CDC25A
| Cell division cycle 25A gene
| 0.00055
| −0.30264
|
CEP3
| CDC42 effector protein 3
| 0.00212
| 0.26513
|
SPEC1
| Small protein effector 1 of CDC42
| 0.00065
| 0.30143
|
APC5
| Anaphase-promoting complex subunit 5
| 0.00109
| −0.28426
|
APC7
| Anaphase-promoting complex subunit 7
| 0.00200
| −0.26684
|
GSPT1
| G1 to S phase transition 1 gene
| 0.00449
| −0.24230
|
MPHOSPH10
| M-phase phosphoprotein 10
| 0.00259
| −0.25931
|
MPHOSPH6
| M-phase phosphoprotein 6
| 0.00069
| −0.29662
|
PA2G4
| Proliferation-associated 2G4 gene, 38 kD
| 0.00003
| −0.36954
|
CTGF
| Connective tissue growth factor
| 0.00138
| 0.27747
|
VEGFC
| Vascular endothelial growth factor C
| 0.00125
| 0.28038
|
=17/123 genes (=14%)
| | | |
Cytokines
| | | |
SCYB13
| Small inducible cytokine B subfamily, member 13
| 0.00178
| 0.27571
|
IL13RA1
| Interleukin 13 receptor α 1
| 0.00001
| 0.39040
|
IL6ST
| Interleukin 6 signal transducer (gp 130, oncostatin M receptor)
| 0.00131
| 0.27905
|
CSF1
| Colony-stimulating factor 1
| 0.00001
| 0.39986
|
=4/48 genes (=8%)
| | | |
Total: 54/465 genes (= 12%)
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