TABLE 1

Binding of [3H]CP 55,940 to the wild-type and N-tail—modified forms of CB1 expressed in HEK 293T cells

Data are presented as the mean ± S.E.M. of two experiments performed in duplicate.

Receptor KdBmax
nM fmol/mg
CB1 4.6 ± 0.6 1700 ± 89
ssCB1 6.1 ± 0.6 2300 ± 110
Δ64CB1 4.8 ± 0.6 1400 ± 110
Δ80CB1 5.7 ± 1.0 2100 ± 120
Δ89CB1 3.9 ± 1.1 2000 ± 190