TABLE 4

Effect of l-DOPA treatment on high- and low-affinity striatal α -CtxMII-sensitive and α -CtxMII-resistant ¹²⁵I-epibatidine binding sites

Binding of ¹²⁵I-epibatidine (400 pM) was inhibited by a range of α -CtxMII concentrations (0.1-3000 nM) using striatal membranes from control and l-DOPA–treated animals. The densities of high- and low-affinity α -CtxMII-sensitive and α -CtxMII-resistant ¹²⁵I-epibatidine binding sites were determined in each case and compared between control and l-DOPA–treated animals. Each value is the mean ± S.E.M. of four animals.