TABLE 2

Regional [³⁵S]TBPS binding to rat brain sections and its modulation by niflumate or furosemide in the presence of 3 μM GABA as revealed by quantitative autoradiography

Values in the presence of niflumate or furosemide are percentages of the corresponding GABA-modulated [³⁵S]TBPS binding value. Values are mean ± S.E. (n = 4).

			+ Niflumate					+ Furosemide
Brain Region	3 μM GABA	% of Basal	10 μM	30 μM	100 μM	300 μM	1,000 μM	100 μM
	nCi/g	%			%
Cerebellum	19 ± 2	11 ± 1	104 ± 12	117 ± 11	135 ± 17	114 ± 18	19 ± 3^**	334 ± 45^**
Granule cell layer	46 ± 2	31 ± 2	144 ± 8^**	160 ± 4^**	200 ± 14^**	189 ± 8^**	54 ± 2^**	332 ± 36^***
Molecular layer	6 ± 2	3 ± 1	58 ± 31	49 ± 22	9 ± 6^*	1 ± 1^*	0 ± 0^*	124 ± 27
Cortex	124 ± 18	24 ± 3	85 ± 11	68 ± 10	34 ± 3^**	12 ± 1^**	1 ± 1^**	95 ± 7
Striatum	79 ± 10	31 ± 3	90 ± 7	72 ± 5^*	39 ± 2^**	10 ± 0^**	0 ± 0^**	106 ± 8
Thalamus	125 ± 9	29 ± 1	86 ± 6	68 ± 5^**	39 ± 2^**	20 ± 1^**	2 ± 0^**	108 ± 8
Hippocampus	35 ± 2	14 ± 1	114 ± 10	104 ± 9	54 ± 2^**	17 ± 2^**	0 ± 0^**	131 ± 12^*
Inferior colliculus	319 ± 14	56 ± 2	63 ± 3^**	50 ± 3^**	25 ± 1^**	10 ± 0^**	0 ± 0^**	87 ± 7

↵* , P < 0.05; ^**, P < 0.01; ^***, P < 0.001, significantly different from the corresponding control values (one-way ANOVA followed by Dunnett's post hoc test for niflumate, Student's t test for furosemide).